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KMID : 0604520000260010199
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Journal of the Society of Cosmetic Scientists of Korea
2000 Volume.26 No. 1 p.199 ~ p.211
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DEVELOPMENT OF POLYETHOXYLATED ASCORBIC ACID AS A WHITENING AGENT
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송영숙/Song, Young-Sook
정봉열/조완구/강세훈/Chung, Bong-Yul/Cho, Wan-Goo/Kang, Seh-Hoon
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Abstract
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A series of novel ascorbic acid derivatives, polyethoxylated ascorbic synthesized by coupling ascorbic acid with polyethylene glycol (PEG) of two (MW: 350 and 550) at the C-2 or C-3 hydroxyl group (2PEAA350, 3PEAA350, 2PEAA550, 3PEAA550) to increase the stability and retain the activity, as a skin whitening agent. Their stability, scavenging activity against free radical, inhibitory activity against tyrosinase and inhibitory activity of melanin synthesis in B16 melanoma cell of PEAAs were evaluated in vitro and compared with those of ascorbic acid and 3-Ο-ethyl ascorbic acid (3ΟEAA), a known stable vitamin C derivative.
Among PEAAs, 2PEAA350 and 2PEAA550 had high scavenging activity against free radical, inhibitory activity against tyrosinase and inhibitory activity of melanogenesis but low stability. 3PEAA350 had high stability and moderate scavenging activity against free radical, inhibitory activity against tyrosinase and inhibitory activity of melanogenesis. The stability, scavenging activity against free radical and inhibitory activity of melanogenesis of 3PEAA350 were higher than those of 30EAA. The most stable 3PEAA350 among PEAAs was nontoxic in various toxicological tests. These results suggest that PEAA would be a good whitening agent for enhancing stability and bioavailability.
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KEYWORD
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